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accession-icon GSE41342
Data from a time course study of gene expression in a mouse model of osteoarthritis
  • organism-icon Mus musculus
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon

Description

The purpose of this study was to characterize the histologic development of OA in a mouse model where OA is induced by destabilization of the medial meniscus (DMM model) and to identify genes regulated during different stages of the disease, using RNA isolated from the joint organ and analyzed using microarrays.427 genes from the microarrays passed consistency and significance filters. There was an initial up-regulation at 2 and 4 weeks of genes involved in morphogenesis, differentiation, and development, including growth factor and matrix genes, as well as transcription factors including Atf2, Creb3l1, and Erg. Most genes were off or down-regulated at 8 weeks with the most highly down-regulated genes involved in cell division and the cytoskeleton. Gene expression increased at 16 weeks, in particular extracellular matrix genes including Prelp, Col3a1 and fibromodulin.The results support a phasic development of OA with early matrix remodelling and transcriptional activity followed by a more quiescent period that is not maintained.

Publication Title

Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis.

Sample Metadata Fields

Sex, Age, Specimen part

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accession-icon GSE18993
Expression profiles from mouse prostate progenitor/stem cells treated with ethanol or 100nM 1,25 dihydroxyvitamin D3
  • organism-icon Mus musculus
  • sample-icon 13 Downloadable Samples
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Description

A major goal in prostate stem cell biology is to identify genes, pathways, or networks that control self-renewal and multilineage differentiation. We hypothesize that 1,25 dihydroxyvitamin D3 can induce differentiation of prostatic progenitor/stem cells, thus serving as an in vitro model with which to study the molecular mechanisms of stem cell differentiation by 1,25 dihydroxyvitamin D3. 1,25 dihydroxyvitamin D3 elicits its effects primarily through transcriptional regulation of genes, so microarray studies were used to gain insight into the cellular response to 1,25 dihydroxyvitamin D3.

Publication Title

Interleukin-1α mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells.

Sample Metadata Fields

Specimen part

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accession-icon GSE28830
Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control (II)
  • organism-icon Mus musculus
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon

Description

Gene expression profiling was carried out on splenocyte mRNA samples collected from 6 animals subject to repeated social threat and 6 animals subject to non-threatening control conditions (pooled into 3 groups of 2). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE26446
Expression data from Rbp2f/f and Rbp2-/- ES cells before and after differentiation
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
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Description

Aberrations in epigenetic processes, such as histone methylation, can lead to cancer. Retinoblastoma Binding Protein 2 (RBP2)(also called JARID1A or KDM5A) can demethylate tri- and di-methylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the MEN1 tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to tumor suppression by pRB. Here we show RBP2 loss promotes cellular differentiation in vitro. We use mouse expression array 430 2.0 array to profile gene expression patterns of Rbp2f/f and Rbp2-/- ES cells in ES cell medium and after 6 days in ES cell medium without LIF.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE14699
Expression data from CD8+ T cells undergoing deletional tolerance
  • organism-icon Mus musculus
  • sample-icon 7 Downloadable Samples
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Description

Peripheral tolerance induction is critical for the maintenance of self-tolerance and can be mediated by immunoregulatory T cells or by direct induction of T cell anergy or deletion. While the molecular processes underlying anergy have been extensively studied, little is known about the molecular basis for peripheral T cell deletion. Here, we determined the gene expression signature of peripheral CD8+ T cells undergoing deletional tolerance, relative to those undergoing immunogenic priming or lymphopenia-induced proliferation. From these data, we report the first detailed molecular signature of cells undergoing deletion.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE26355
Expression data from early and late born Atoh1 lineages within the E14.5 rhombomere 1 and isthmus
  • organism-icon Mus musculus
  • sample-icon 5 Downloadable Samples
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Description

Following neural tube closure at around E9.5, the rhombic lip within the rhombomere 1/isthmus region ("upper rhombic lip") produces a sequence of neuronal lineages that populate the brainstem and cerebellum. The transcription factor Atoh1 (Math1) is required for this specialized neurogenesis, although the genetic programs that delineate the temporal cell fate changes downstream of Atoh1 are not well characterized. We examined the gene expresion changes that take place within Atoh1 lineages

Publication Title

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.

Sample Metadata Fields

Specimen part

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accession-icon GSE16660
Differential gene expression in prefrontal cortex from mice subject to social threat vs. control
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
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Description

Gene expression profiling was carried out on prefrontal cortex mRNA samples collected from 10 animals subject to repeated social threat (pooled into 2 groups of 5) and 10 animals subject to non-threatening control conditions (pooled into 2 groups of 5). The primary research question is whether gene expression differs in prefrontal cortex tissue from animals exposed to social threat vs non-threatening control conditions.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE16661
Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon

Description

Gene expression profiling was carried out on splenocyte mRNA samples collected from 10 animals subject to repeated social threat (pooled into 2 groups of 5) and 10 animals subject to non-threatening control conditions (pooled into 2 groups of 5). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions.

Publication Title

Computational identification of gene-social environment interaction at the human IL6 locus.

Sample Metadata Fields

Specimen part

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accession-icon GSE10606
F9 Embryonal Carcinoma cell line
  • organism-icon Mus musculus
  • sample-icon 3 Downloadable Samples
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Description

Expression profile for undifferentiated F9 Embryonal Carcinoma cell line

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE27719
Lung adenocarcinoma invasion and progression
  • organism-icon Mus musculus, Homo sapiens
  • sample-icon 65 Downloadable Samples
  • Technology Badge Icon

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-β type II receptor.

Sample Metadata Fields

Sex, Specimen part

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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