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accession-icon GSE13231
The effect of inherited polymorphism on prognostic gene expression signatures
  • organism-icon Mus musculus
  • sample-icon 42 Downloadable Samples
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Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

The origins of breast cancer prognostic gene expression profiles.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE13227
(AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 Thymus expression data
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon

Description

F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from normal tissues

Publication Title

The origins of breast cancer prognostic gene expression profiles.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE13223
(AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 bone marrow expression data
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon

Description

F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from normal tissues

Publication Title

The origins of breast cancer prognostic gene expression profiles.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE13222
(AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 blood expression data
  • organism-icon Mus musculus
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon

Description

F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from normal tissues

Publication Title

The origins of breast cancer prognostic gene expression profiles.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE64750
Lung expression data from highly pathogenic H5N1 virus infected and uninfected mice
  • organism-icon Mus musculus
  • sample-icon 22 Downloadable Samples
  • Technology Badge Icon

Description

Susceptible and Resistant mouse strain, e.g. DBA/2J and C57BL/6J respectively, were inoculated with a highly pathogenic H5N1 influenza A virus (A/Hong Kong/213/2003) for 72 hours.

Publication Title

Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.

Sample Metadata Fields

Sex

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accession-icon GSE10965
Comparison of the transcriptional profiles of the retinal pigmental epithelium/choroid from young and old mice
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon

Description

To characterize underlying changes in the retinal pigment epithelium (RPE)/choroid with age, we produced gene expression profiles for the RPE/choroid and compared the transcriptional profiles of the RPE/choroid from young and old mice. The changes in the aged RPE/choroid suggest that the tissue has become immunologically active. Such phenotypic changes in the normal aged RPE/choroid may provide a background for the development of age-related macular degeneration.

Publication Title

The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE45577
Profiling of glycerol- and CTX-induced models of muscle regeneration in mice
  • organism-icon Mus musculus
  • sample-icon 48 Downloadable Samples
  • Technology Badge Icon

Description

Utilizing glycerol and cardiotoxin (CTX) injections in the tibialis anterior muscles of M. musculus provides models of skeletal muscle damages followed by skeletal muscle regeneration. In particular, glycerol-induced muscle regeneration is known to be associated with ectopic adipogenesis. We characterized genome-wide expression profiles of tibialis anterior muscles from wild-type mice injured by either glycerol or CTX injection. Our goal was to detect gene expression changes during the time course of glycerol-induced and CTX-induced muscle regeneration models, that can lead to ectopic adipocyte accumulation.

Publication Title

Genomic profiling reveals that transient adipogenic activation is a hallmark of mouse models of skeletal muscle regeneration.

Sample Metadata Fields

Sex, Age, Specimen part

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accession-icon GSE38681
Lyl-1 knockout vs wildtype Lymphoid Primed Multipotent Progenitors (LMPPs)
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon

Description

We compared gene expression differences in Lyl-1 knockout vs wildtype LMPPs

Publication Title

The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors.

Sample Metadata Fields

Specimen part

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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