publication_authors:Drechsel D Results

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Microarray (122)

Platform

Affymetrix Mouse Genome 430 2.0 Array (mouse4302) (73)

Affymetrix Human Gene 1.0 ST Array (hugene10st) (48)

Affymetrix Murine Genome U74A Version 2 Array (mgu74av2) (9)

Affymetrix Zebrafish Genome Array (zebrafish) (1)

Includes Publication

GSE12134

The transcription factor AP2 regulates the number of basal progenitors

Mus musculus
12 Downloadable Samples

Description

Understanding the mechanisms that specify neuronal subtypes is important to unravel the complex mechanisms of neuronal circuit assembly. Here we have identified a novel role for the transcription factor AP2 in progenitor and neuronal subtype specification in the cerebral cortex. Conditional deletion of AP2 causes misspecification of basal progenitors starting at

Publication Title

AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.

Sample Metadata Fields

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GSE17709

Gene expression analysis of a podocyte specific PTIP deletion in mouse glomerular preparations at 1 month of age

Mus musculus
18 Downloadable Samples

Description

Glomerular RNA comparison between wild-type and podocyte specific deletion of the PTIP gene in 1 month old kidneys. The PTIP gene was deleted using a floxed allele and a Podocin-Cre driver strain.

Publication Title

Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.

Sample Metadata Fields

Specimen part

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GSE38729

Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio)

Danio rerio
1 Downloadable Sample

Description

Domesticated animal populations often show profound reductions in predator avoidance and fear-related behavior compared to wild populations. These reductions are remarkably consistent and have been observed in a diverse array of taxa including fish, birds, and mammals. Experiments conducted in common environments indicate that these behavioral differences have a genetic basis. In this study, we quantified differences in fear-related behavior between wild and domesticated zebrafish strains and used microarray analysis to identify genes that may be associated with this variation.

Publication Title

Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio).

Sample Metadata Fields

Sex, Specimen part

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GSE4035

Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression (palme-affy-mouse-84746)

Mus musculus
20 Downloadable Samples

Description

These data are from the brains (amygdala and hippocampus) of mice originally derived from a cross between C57BL/6J and DBA/2J inbred strains. We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning, which is a measure of fear learning. We selected for a total of 4 generations. Fear learning differed in the selected lines and this difference was stronger with each successive generation of selection. These mice also showed differences for measures of anxiety-like behavior, but were not different for tests of non-fear motivated learning, suggesting that selection altered alleles that are specifically involved in emotional behaviors. We identified several QTLs for the selection response. We used Affymetrix microarrays to identify differentially expressed genes in the amygdala and hippocampus of mice from the final generation of selection. Amygdala and hippocampus samples were rapidly dissected out of experimentally nave mice f rom each selected line. Three samples were pooled and hybridized to each array. Experimentally nave mice were used because the behavior of the mice can be reliably anticipated due to their lineage. Thus, these gene expression differences are not due to the response to human handling, foot shock or fear-inducing conditioned stimuli. We have a second similar study that focuses on a different selected population that was based on C57BL/6J and A/J mice (see GES4034).

Publication Title

Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression.

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GSE72054

Expression data of regenerating embryonic mouse hearts

Mus musculus
10 Downloadable Samples

Description

We have recently shown a remarkable regenerative capacity of the prenatal heart using a genetic model of mosaic mitochondrial dysfunction in mice. This model is based on inactivation of the X-linked gene encoding holocytochrome c synthase (Hccs) specifically in the developing heart. Loss of HCCS activity results in respiratory chain dysfunction, disturbed cardiomyocyte differentiation and reduced cell cycle activity. The Hccs gene is subjected to X chromosome inactivation, such that in females heterozygous for the heart conditional Hccs knockout approximately 50% of cardiac cells keep the defective X chromosome active and develop mitochondrial dysfunction while the other 50% remain healthy. During heart development, however, the contribution of HCCS deficient cells to the cardiac tissue decreases from 50% at midgestation to 10% at birth. This regeneration of the prenatal heart is mediated by increased proliferation of the healthy cardiac cell population, which compensate for the defective cells and allow the formation of a fully functional heart at birth. Here we performed microarray expression ananlyses on 13.5 dpc control and heterozygous Hccs knockout hearts to identify molecular mechanisms that drive embryonic heart regeneration.

Publication Title

Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.

Sample Metadata Fields

Sex, Specimen part

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GSE7396

TfRc Dependent Gene Expression in Embryonic Renal Cells

Mus musculus
4 Downloadable Samples

Description

We investigated the ability of transferrin receptor1 (TfRc) knockout cells to populate different domains of the developing kidney by using a chimeric approach. The TfRc cells developed into all segments of the developing nephron, but there was a relative exclusion from the ureteric bud and a positive bias towards the stromal compartment. Here we conducted a microarray analysis of differential gene expression between TfRc deficient and wild type (wt) cells in chimeric embryonic kidneys derived from embryos created by blastocyst injection of wt blastocysts with TfRc-/- green fluorescent protein-expressing (GFP+) embryonic stem cells.